1. What Is Creatinine Clearance?

Creatinine clearance is a measure of the rate at which creatinine is cleared from the blood by the kidneys. It provides an estimate of glomerular filtration rate (GFR) and is commonly used to assess kidney function.

2. How Does The Calculator Work?

The calculator uses the creatinine clearance formula:

Where:

• \( CrCl \) — Creatinine clearance (mL/min)
• \( UCr \) — Urine creatinine concentration (mg/dL)
• \( V \) — Urine volume per minute (mL/min)
• \( PCr \) — Plasma creatinine concentration (mg/dL)

Explanation: This formula calculates the volume of plasma cleared of creatinine per minute, providing a direct measurement of kidney filtration capacity.

3. Importance Of Creatinine Clearance Calculation

Details: Creatinine clearance is crucial for assessing kidney function, monitoring renal disease progression, adjusting medication dosages for renally excreted drugs, and evaluating overall renal health.

4. Using The Calculator

Tips: Enter urine creatinine in mg/dL, urine volume in mL/min, and plasma creatinine in mg/dL. All values must be positive numbers. For 24-hour urine collection, convert total volume to mL/min by dividing by 1440.

5. Frequently Asked Questions (FAQ)

Q1: What Is The Difference Between Creatinine Clearance And eGFR?
A: Creatinine clearance is measured using urine and blood samples, while eGFR is estimated from blood creatinine alone using equations like CKD-EPI or MDRD.

Q2: What Are Normal Creatinine Clearance Values?
A: Normal values are approximately 95-125 mL/min for men and 85-115 mL/min for women, decreasing with age.

Q3: How Do I Collect A 24-Hour Urine Sample?
A: Discard first morning urine, then collect all urine for next 24 hours including next morning's first urine. Keep refrigerated during collection.

Q4: What Factors Affect Creatinine Clearance?
A: Age, gender, muscle mass, diet, medications, hydration status, and kidney function can all affect creatinine clearance values.

Q5: When Is Creatinine Clearance Preferred Over eGFR?
A: In patients with extremes of age, muscle mass, or body size, and for precise drug dosing of renally eliminated medications.