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Cockcroft-Gault Equation:
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The Cockcroft-Gault equation estimates creatinine clearance (CrCl) from serum creatinine, age, weight, and gender. It is widely used for drug dosing adjustments in patients with renal impairment and provides an estimate of glomerular filtration rate.
The calculator uses the Cockcroft-Gault equation:
Where:
Explanation: The equation estimates creatinine clearance based on demographic and laboratory values, with adjustment for gender differences in muscle mass and creatinine production.
Details: Accurate creatinine clearance estimation is essential for appropriate drug dosing in patients with renal impairment, assessing kidney function, and monitoring for drug toxicity in medications eliminated by the kidneys.
Tips: Enter age in years, weight in kilograms, serum creatinine in mg/dL, and select gender. All values must be valid (age between 1-120, weight > 0, creatinine > 0).
Q1: What is the difference between eCrCl and eGFR?
A: eCrCl estimates creatinine clearance while eGFR estimates glomerular filtration rate. Both assess kidney function but use different equations and may give slightly different results.
Q2: When is Cockcroft-Gault preferred over other equations?
A: Cockcroft-Gault is often preferred for drug dosing adjustments as many medication guidelines were developed using this equation.
Q3: What are normal creatinine clearance values?
A: Normal values are approximately 90-120 mL/min for young adults, declining with age. Values below 60 mL/min indicate renal impairment.
Q4: Are there limitations to the Cockcroft-Gault equation?
A: Less accurate in extremes of age, obesity, malnutrition, amputees, and patients with rapidly changing kidney function or unstable creatinine levels.
Q5: Should ideal body weight be used?
A: For obese patients, some guidelines recommend using ideal body weight rather than actual body weight for more accurate estimation.