Estimated Creatinine Clearance Calc

Cockcroft-Gault Equation:

\[ CrCl = \frac{(140 - Age) \times Wt \times (0.85 \text{ if female})}{72 \times SCr} \]

Age:

years

Weight:

Serum Creatinine (SCr):

mg/dL

Gender:

Creatinine Clearance (CrCl):

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1. What is the Cockcroft-Gault Equation?

The Cockcroft-Gault equation estimates creatinine clearance (CrCl) from serum creatinine, age, weight, and gender. It is widely used for drug dosing adjustments in patients with renal impairment and provides an estimate of glomerular filtration rate.

2. How Does the Calculator Work?

The calculator uses the Cockcroft-Gault equation:

\[ CrCl = \frac{(140 - Age) \times Wt \times (0.85 \text{ if female})}{72 \times SCr} \]

Where:

\( CrCl \) — Creatinine clearance (mL/min)
\( Age \) — Age in years
\( Wt \) — Weight in kilograms
\( SCr \) — Serum creatinine (mg/dL)
0.85 — Female multiplier

Explanation: The equation estimates the rate at which creatinine is cleared from the blood by the kidneys, providing an approximation of kidney function.

3. Importance of Creatinine Clearance Calculation

Details: Accurate creatinine clearance estimation is crucial for medication dosing adjustments, assessing renal function, and monitoring patients with kidney disease or those receiving nephrotoxic drugs.

4. Using the Calculator

Tips: Enter age in years, weight in kilograms, serum creatinine in mg/dL, and select gender. All values must be valid (age between 1-120, weight > 0, creatinine > 0).

5. Frequently Asked Questions (FAQ)

Q1: Why use Cockcroft-Gault equation?
A: It is one of the most widely validated equations for estimating creatinine clearance and is commonly used for drug dosing adjustments in clinical practice.

Q2: What are normal CrCl values?
A: Normal creatinine clearance is approximately 95-125 mL/min for men and 85-115 mL/min for women, though values decline with age.

Q3: When should creatinine clearance be measured?
A: When assessing renal function for drug dosing, evaluating kidney disease progression, or monitoring patients at risk for renal impairment.

Q4: Are there limitations to this equation?
A: Less accurate in elderly patients, obese individuals, those with unstable creatinine levels, and patients with extreme body habitus.

Q5: Should ideal body weight be used?
A: For obese patients, some clinicians use ideal body weight instead of actual weight, though practice varies.