Estimate Creatinine Clearance Calculator

Cockcroft-Gault Equation:

\[ CrCl = \frac{(140 - Age) \times Weight}{72 \times Scr} \times 0.85 \text{ (if female)} \]

Age:

years

Weight:

Serum Creatinine (Scr):

mg/dL

Gender:

Creatinine Clearance (CrCl):

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1. What is the Cockcroft-Gault Equation?

The Cockcroft-Gault equation estimates creatinine clearance (CrCl) from serum creatinine, age, weight, and gender. It is widely used for drug dosing adjustments in patients with renal impairment and provides an estimate of kidney function.

2. How Does the Calculator Work?

The calculator uses the Cockcroft-Gault equation:

\[ CrCl = \frac{(140 - Age) \times Weight}{72 \times Scr} \times 0.85 \text{ (if female)} \]

Where:

\( Age \) — Age in years
\( Weight \) — Body weight in kilograms
\( Scr \) — Serum creatinine in mg/dL
\( 0.85 \) — Female gender multiplier

Explanation: The equation estimates creatinine clearance based on demographic and laboratory parameters, with adjustment for gender differences in muscle mass and creatinine production.

3. Importance of Creatinine Clearance Calculation

Details: Accurate creatinine clearance estimation is crucial for drug dosing adjustments, assessing renal function, and guiding treatment decisions in patients with kidney impairment.

4. Using the Calculator

Tips: Enter age in years, weight in kilograms, serum creatinine in mg/dL, and select gender. All values must be valid (age between 1-120, weight > 0, creatinine > 0).

5. Frequently Asked Questions (FAQ)

Q1: Why use Cockcroft-Gault equation?
A: It is one of the most widely validated equations for estimating creatinine clearance and is commonly used for drug dosing adjustments in clinical practice.

Q2: What are normal CrCl values?
A: Normal creatinine clearance is approximately 95-125 mL/min for men and 85-115 mL/min for women, declining with age.

Q3: When should creatinine clearance be measured?
A: When assessing renal function for drug dosing, evaluating kidney disease progression, or monitoring patients with known renal impairment.

Q4: Are there limitations to this equation?
A: Less accurate in extremes of age, obesity, malnutrition, amputees, and patients with rapidly changing kidney function or unstable creatinine levels.

Q5: Should ideal body weight be used?
A: For obese patients, some guidelines recommend using ideal body weight rather than actual body weight for more accurate estimation.