Augmented Renal Clearance Calculator

ARC Equation:

\[ ARC = \frac{(140 - Age) \times Weight \times 1.9 \text{ (male)}}{72 \times SCr} \]

Age:

years

Weight:

Serum Creatinine (SCr):

mg/dL

Gender:

ARC:

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1. What is Augmented Renal Clearance?

Augmented Renal Clearance (ARC) is a phenomenon characterized by enhanced renal elimination of circulating solutes, typically defined as a creatinine clearance >130 mL/min/1.73m². It's commonly observed in critically ill patients, particularly those with sepsis, trauma, or burns.

2. How Does the Calculator Work?

The calculator uses the ARC estimation equation:

\[ ARC = \frac{(140 - Age) \times Weight \times 1.9 \text{ (male)}}{72 \times SCr} \]

Where:

\( Age \) — Age in years
\( Weight \) — Body weight in kilograms
\( SCr \) — Serum creatinine in mg/dL
\( 1.9 \) — Male coefficient (1.0 for females)

Explanation: This equation estimates creatinine clearance and helps identify patients with augmented renal function who may require adjusted medication dosing.

3. Importance of ARC Calculation

Details: Identifying ARC is crucial in critical care settings as it can lead to subtherapeutic drug concentrations, particularly for antibiotics and other renally eliminated medications, potentially compromising treatment efficacy.

4. Using the Calculator

Tips: Enter age in years, weight in kilograms, serum creatinine in mg/dL, and select gender. All values must be valid (age between 1-120, weight > 0, creatinine > 0).

5. Frequently Asked Questions (FAQ)

Q1: What defines augmented renal clearance?
A: ARC is typically defined as a measured creatinine clearance >130 mL/min/1.73m², indicating enhanced renal drug elimination.

Q2: Which patient populations are at risk for ARC?
A: Critically ill patients, particularly those with sepsis, trauma, burns, pancreatitis, and younger patients with preserved organ function.

Q3: Why is ARC clinically significant?
A: ARC can lead to subtherapeutic concentrations of renally cleared drugs, especially antibiotics, potentially resulting in treatment failure.

Q4: How should medication dosing be adjusted for ARC?
A: Higher doses, more frequent administration, or extended infusions may be required for renally eliminated medications in patients with ARC.

Q5: Are there limitations to this estimation?
A: This is an estimation formula. For precise medication dosing in critical care, measured creatinine clearance via urine collection is preferred.